The Wood Avenue Historic District is a historic district in Florence, Alabama. The residential neighborhood was primarily developed after Reconstruction, although five houses date from before the Civil War. By the time of Florence's economic boom of the 1880s, the most fashionable upper-class neighborhood in Florence, today known as the Sannoner Historic District, had already been filled in, leading development to move to Wood Avenue to the west. Most homes built during this time were large, Victorian structures, including many elaborate examples of Queen Anne architecture.